{"id":979,"date":"2011-08-16T11:22:29","date_gmt":"2011-08-16T11:22:29","guid":{"rendered":"http:\/\/junq.info\/?p=979"},"modified":"2011-08-16T11:22:29","modified_gmt":"2011-08-16T11:22:29","slug":"how-could-metabolic-pathways-of-unknown-microbes-be-revealed","status":"publish","type":"post","link":"http:\/\/junq.info\/?p=979","title":{"rendered":"How could metabolic pathways of unknown microbes be revealed?"},"content":{"rendered":"<p><em>Question of the Week, 16.8.2011<\/em><\/p>\n<p>Due to the introduction of next-generation sequencing technologies, a<\/p>\n<p>lot of habitats have been sequenced with the aim of getting insights<\/p>\n<p>into microbial communities provided by metagenomic analysis [1]. Based<\/p>\n<p>on this possibility, many habitats with harsh life conditions have been<\/p>\n<p>sequenced, such as deep sea thermal vents, desert or Antarctic frozen<\/p>\n<p>lakes. However, in most cases only few or no related organisms are known<\/p>\n<p>whereby the identification of genes and enzymes of the microbial<\/p>\n<p>community is hampered [2]. If sequence similarity searches are not<\/p>\n<p>applicable because of the inaccuracy and the high amount of hypothetical<\/p>\n<p>proteins in unknown habitats, how could a higher amount of genes be<\/p>\n<p>identified and therefore metabolic reconstruction be relieved?<\/p>\n<p>[1] Jo Handelsman: Metagenomics: Application of Genomics to Uncultured<\/p>\n<p>Microorganisms. <em>Microbiology and Molecular Biology Reviews<\/em>, <strong>68<\/strong>(4), 2004.<\/p>\n<p>[2] Philip Hugenholtz and Gene W. Tyson: Metagenomics. <em>Nature<\/em>, <strong>455<\/strong>, 2008.<\/p>\n<p>Johannes Werner<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Due to the introduction of next-generation sequencing technologies, a<\/p>\n<p>lot of habitats have been sequenced with the aim of getting insights<\/p>\n<p>into microbial communities provided by metagenomic analysis&#8230; (Question of the Week, 16.8.2011)<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[6],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/junq.info\/index.php?rest_route=\/wp\/v2\/posts\/979"}],"collection":[{"href":"http:\/\/junq.info\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/junq.info\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/junq.info\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/junq.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=979"}],"version-history":[{"count":1,"href":"http:\/\/junq.info\/index.php?rest_route=\/wp\/v2\/posts\/979\/revisions"}],"predecessor-version":[{"id":980,"href":"http:\/\/junq.info\/index.php?rest_route=\/wp\/v2\/posts\/979\/revisions\/980"}],"wp:attachment":[{"href":"http:\/\/junq.info\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/junq.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=979"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/junq.info\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}