Vol.10 issue 1 2020

Mar 102020
 
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Traffic development

Absolute nothingness ( Śūnyata ) is one of the most exciting notions in Buddhism. Essentially, it cannot be interpreted anyhow but can be thought of as Ultimate Reality[1]. In Mediterranean tradition, ancient cosmologists introduced another term that sounds more familiar – The Chaos. It was associated with the infinite ocean and expressed an initial state of cosmos in potentia[2]. Not to get numb by the immensity of this semantic unit, we can consider chaos as noise having an infinite spectrum of all conceivable frequencies. And through interaction with external conditions, certain modes manage to become more pronounced as, for example, in the process of stimulated emission build-up in the laser[3] or during the process of natural selection in the theory of evolution.[4]

Traffic development


In the context of road traffic development, we can define the situation in ancient times as the initial chaotic state. As there were no roads as such, the traffic was chaotic. With the evolution of horse-drawn transport, the road map was developing. However, the roads were still only directions along which one could get from one place to another.

The situation changed when engine cars jolted the slow and stagnant horse traffic. Between the man and the road there was no middle link anymore that could choose a better way within the given direction on its own. Nonetheless, engine-drawn transport had an obvious advantage of higher achievable speed. In turn, the desire to move faster and faster required less scattering at the surface roughness, which inevitably resulted in roads getting smoother, i.e., less chaotic. In the meantime, the assembly line was progressing drastically and both factors lead to a dense cloud of potentially fast cars. But people were still scratching their heads why the average speed of the road traffic was not increasing. After a while, they figured out who is to blame in the residual scattering – the interaction of the drivers themselves with each other. With the absence of any predefined rules, everyone had to slow down and likely change the direction to avoid physical interaction with another participant of the traffic. Thus, the necessity of the traffic regulations was obvious.

The first “Convention with respect to the international circulation of motor vehicles” was signed in Paris in 1909[5]. Among others, it contained the sign depicted in Fig. 1, which indicated the road intersection. And naturally, originating from the ship traffic, the habitual priority-to-the-right rule was established to regulate the right-of-way for two vehicles with intersecting directions. Later a set of traffic regulations was complemented with priority signs and traffic lights.

Gödel’s theorems

In 1930 Kurt Gödel presented two theorems reflecting insuperable limitations of formal arithmetics. These theorems had a direct relation to the second problem from Hilbert’s list asking for the proof that arithmetics is consistent.[7] The first Gödel’s theorem (in Rosser form) states that within any consistent formal system S, one can come up with expression A that can be neither proved nor disproved[8]. In other words, the axiomatic system S is incomplete. Hao Wang published in his Logical Journey[9] the full text that Gödel had written about his discovery of the incompleteness theorems:

“In the summer of 1930 I began to study the consistency problem of classical analysis. It is mysterious why Hilbert wanted to prove directly the consistency of analysis by finitary methods. I saw two distinguishable problems: to prove the consistency of number theory by finitary number theory and to prove the consistency of analysis by number theory <…> Since the domain of finitary number theory was not well-defined, I began by tackling the second half <…> I represented real numbers by predicates in number theory <…> and found that I had to use the concept of truth (for number theory) to verify the axioms of analysis. By an enumeration of symbols, sentences and proofs within the given system, I quickly discovered that the concept of arithmetic truth cannot be defined in arithmetic. If it were possible to define truth in the system itself, we would have something like the liar paradox, showing the system to be inconsistent <…> Note that this argument can be formalized to show the existence of undecidable propositions without giving any individual instances. (If there were no undecidable propositions, all (and only) true propositions would be provable within the syosmos in potestem. But then we would have a contradiction.) <…> In contrast to truth, provability in a given formal system is an explicit combinatorial property of certain sentences of the system, which is formally specifiable by suitable elementary means…”

Traffic regulations in the context of the 1st Gödel’s theorem

We can consider any set of interrelated rules, including traffic regulations, as a formal axiomatic system where each axiom is not subject to prove and serves as a basis for further deriving the formulas and theorems (or behavior in a traffic situation). Clearly, the traffic regulations are consistent because otherwise, the number of car crashes would be much higher. Hence, according to the 1st Gödel’s theorem, the system is incomplete. This means that there would always exist a situation, which cannot be resolved regardless of the number of regulations (axioms) contained in the system.

The example of such a situation can be observed on the road intersection regulated by priority-to-the-right rule depicted in Fig. 2. Here four vehicles coming from every direction want to pass this intersection each going straight. There is no way to resolve this situation (to derive the formula) within the traffic regulations system and the drivers in every certain situation are supposed to make the decision: who has the priority.

We can incrementally enhance our axiomatic system by introducing another rule to resolve such a dead-end situation. A rule that gives priority to go first, say, to a red car. Again, four red cars on the same road crossing end up with the same confusion. As long as we add the rules (axioms) into the system enumerably, which is the case for the traffic regulations, such situations will always appear. Introducing the priority signs, constant or variable in time, like traffic lights, or topological road junctions (see Fig. 3) can only decrease the probability of this situation emerging.

Nowadays, most of the intersections are controlled (or topologically resolved). And let’s assume that the preposterous situation with four red cars trying to figure out the right-of-way on the uncontrolled intersection hasn’t happened up to the moment in our complex but finite system of road traffic. Hence, the drivers’ behavior seems to be fully governed with the traffic regulations. However, there still is a possibility of an unresolvable situation, namely, if one comes up with an expression: “I’m not going to obey the rules. For the axiomatic system of traffic regulations, this expression serves as a “liar paradox” and cannot be resolved. Thus people had to come up with the penalty system for acceptable performance of the traffic regulations. But again, it is impossible to nullify the probability of such a situation emerging.

Instead of conclusion

The aim of this text was not to establish a solid theory in either mathematics or law, and the presented examples may not be in strict compliance with the described statements. However, the author finds entertaining the fact that there are bridges between different islands of knowledge accumulated by mankind over the infinite ocean of the unknown.

— Sergei Sobolev

Read more:
[1] D. Mathers, M. Miller, O. Ando. Self and No-Self: Continuing the Dialogue Between Buddhism and Psychotherapy. 2013 Routledge
[2] http://www.plato.spbu.ru/TEXTS/lebedev/1/ferekid.htm
[3] W. Koechner. Solid-State Laser Engineering, 2006 Springer
[4] C. Darwin. The origin of species by means of natural selection; or, the preservation of favoured races in the struggle for life. 1859 London
[5] Convention with Respect to the International Circulation of Motor Vehicles. The American Journal of International Law Vol. 4, No. 4, Supplement: Official Documents (Oct., 1910), pp. 316-328
[6] https://upload.wikimedia.org/wikipedia/commons/f/f2/1909_Paris_Convention_road_signs.jpg
[7] D. Hilbert. “Mathematical Problems”. Bulletin of the American Mathematical Society. 8 (10): 437–479, 1902.
[8] Introduction to metamathematics. S. Kleene, 1952 D. Van Nostrand Company, Inc.
[9] H. Wang. A Logical Journey. From Gödel to Philosophy. 1996 The MIT Press.
[10] https://www.archdaily.com/64354/pearl-river-necklace-nl-architects/

Jan 122020
 
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Just the thought of getting in touch with or even ingesting urine repels many people. But medical treatment with urine – also called urotherapy – has been a valuable approach in the traditional medicine of many cultures over the last centuries. Usually, endogenous urine is used but animals are also popular sources. The utilization of urine in conventional medicine is not uncommon too. Urokinase, for example, can be isolated from (human) urine and is an important thrombolytic agent.[1] The drug Premarin®, which is used for hormone treatment, contains estrogens that are extracted from the urine of pregnant mares.[2]

Besides milk, camel (i. e. camelus dromedarius) urine plays a special role for desert dwelling people like the Bedouin. Its use was advised by Prophet Mohammed, thus it has found its way into the Islamic prophetic medicine.[3] Apparently, this body liquid cures diseases like tuberculosis, hepatitis, digestion problems, impotence, hemorrhoids, and flatulence, just to name a few. In 2013, one liter of urine from a virgin camel was worth about 15 € (ca 20 USD) in Yemen, where it is not only used for universal medical treatment but also as a cosmetic product for skin and hair care.[4]

src="Dromadaire4478.jpg" alt="Journal of Unsolved Questions (JUnQ): A Moroccan dromedary camel ‒ a favored livestock of Bedouin people. It's urine is said to be medicative."
A Moroccan dromedary camel ‒ a favored livestock of Bedouin people.[5] (public domain – wikimedia commons)

Conventional medicine offers plenty of pharmaceutical cancer treatments which are a blessing and a curse for the patients at the same time. Besides the tedious and exhaustive treatment, patients are confronted with severe side-effects including nausea, fatigue, hair loss, inflammation, and temporary immunodeficiency. The demand for alternatives that are at the same time highly effective, easy to use, mild, and in the best case based on renewable resources is therefore very high.

Camel urine has long been claimed to be an efficient cancer treatment but detailed research on its actual potency and effect on human health is scarce. The soothing effect of pure camel urine on digestive problems can sufficiently be explained through its relatively high content of electrolytes like sodium and zinc as found by Al-Attas, in 2009 – a result that certainly might be achieved just as well by drinking a bouillon.[6] Kohrshid et al. were the first to show an inhibiting effect of lyophilized camel urine on carcinoma cells in animals.[7] In 2011, Alhaider et al. found that treatment of murine hepatoma cells (Hepa 1c1c7, i. e. liver cells) with camel urine inhibited the induction of Cyp 1a1 (a well-known cancer-activator) gene expression by TCDD, a potent Cyp 1a1 inducer and a known carcinogen. Among virgin, pregnant, and lactating camels, the virgin’s urine was found to be most potent while the urine of pregnant camels showed the least potency.[8] One year later, Khorsihd et al. showed that the potency of camel urine to reduce a specific type of lung cancer cells (A549) is somewhat dependent on the breed (Majaheem urine was found to be more effective than Magateer urine) and the age of the camels. The depletion of the cancer cells ranged between 85‒93% of the starting cell number.[9,10] The bioactive subfraction PMF which is believed to be responsible for these effects is obtained from lyophilized camel urine (in literature frequently called PM701).[10] Clinical trials on the oral uptake of PM701 fractions showed no negative effects on human health so far.[11] Apparently, the urine contains a high amount of antibodies of such a small size, that they can be easily absorbed by the patient’s digestive system.[12] Other experiments also show antimicrobial effects of camel urine on bacteria and fungi.[13] Aiming at the environmentally friendly substitution of synthetic agents which are usually obtained from complex multistep reactions this approach is most honorable. It is exciting to see that a waste product has the potential to cure severe diseases although much more research must be done on this subject to clearly verify the efficacy. After all, urine is an excretion that contains various less beneficial digestive metabolites, and even toxins that the body wants to get rid of and indisputable evidence for the efficacy and safety of the PM701 fractions are vital.

For those people who are curious enough to try camel urine for whatever reason but are too disgusted by the idea to drink it pure, a solution might be on the way: there are capsules of PM701, or PMF respectively, but they are not yet available on the market.[10] Another alternative might be camel milk which sounds much more enjoyable and is supposed to be a medicine just as magical as camel urine. It is said to “reduce blood sugar […] solve the problems of autism in children, enhance the immunity of the body…” and many more.[14] Alas, some bad news comes from the World Health Organization (WHO) concerning the use of camel milk and urine: shortly after the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Saudi Arabia in the year 2012 dromedary camels were found to be zoonotic transmitters, meaning that the virus is rapidly transferred from animals to humans – just as we experience right now with the latest outbreak of a coronavirus (COVID-19).[15] As a consequence the WHO advises to avoid contact with camels or consuming raw camel milk and urine.[16] This surely dampens the enthusiasm to utilize camel urine and we might have to wait a few years more for some groundbreaking results in cancer research.

‒ Tatjana Dänzer

References

[1] “Abstracts of Papers Read”. American Journal of Physiology. Legacy Content., 1952, 171, 704–781.
[2] D. Brügger, „Hormone aus Stutenharn“, pharma-kritik, 2019, Nr. 5/6/1997.
[3] Alhaidar, A., Gader, A. G. M. A., Mousa, S. A., The Journal of Alternative and Complementary Medicine, 2011, 17, 803‒808.
[4] https://www.vice.com/en_us/article/4w7gvn/drinking-camel-urine-in-yemen-fob-000300-v20n8.
[5] https://upload.wikimedia.org/wikipedia/commons/4/40/Dromadaire4478.jpg
[6] Al-Attas, A. S., Arab J. Nucl. Sci. Appl., 2009, 42, 59–67.
[7] Khorshid F., International Journal of Pharmacology, 2008, 4, 443‒451
[8] Alhaidar, A. A.; El Gendy, M. A. M.; Korashy, H. M.; El-Kadi, A. O. S., Journal of Ethnopharmacology, 2011, 133, 184–190.
[9] Alghamdi, Z.; Khorshid, F., Journal of Natural Sciences Research, 2012, 2, 9‒16.
[10] Khorshid, F. A., 2009, US 20090297622.
[11] Khorshid, F. A., Alshazly, H., Al Jefery, A., Osman, M. A.-M., Journal of Pharmacology and Toxicology 2010, 5, 91‒97.
[12] Hamers-Casterman, C.; Atarhouch, T.; Muyldermans, S.; Robinson, G., Hammers, C.; Songa, E. B.; Bendahman, N. and Hammers, R., Nature, 1993, 363, 446‒448.
[13] Mostafa, M. S.; Dwedar, R. A., British Journal of Pharmaceutical Research, 2016, 13, 1‒6.
[14] Hammam, A. R. A., Emirates Journal of Food and Agriculture, 2019, 31, 148‒152.
[15] https://www.eurosurveillance.org/content/10.2807/1560-7917.ES2014.19.16.20781.
[16] https://www.who.int/csr/don/08-january-2020-mers-uae/en/.