Could iron serve as a similarly good catalyst in cross-coupling reactions as palladium?

Question of the Week, 15.11.2010

This year’s Nobel Prize in chemistry was awarded to a group of scientists that engaged in designing palladium-catalyzed reactions opening a plethora of new routes in organic synthesis. But palladium is expensive and also toxic. For more than two decades now chemists have been investigating the ability of iron to serve as a catalyst in cross coupling reactions and in some respect they have been very successful. But still iron remains less flexible and less reliable as a cross-coupling agent.

Read more:

Iron-Catalyzed Cross-Coupling Reactions

A. F?rstner, A. Leitner, M. Mendez and H. Krause, J. Am. Chem. Soc. 2002, 124 (46), 13856-13863

Link: http://pubs.acs.org/doi/abs/10.1021/ja027190t

The Promise and Challenge of Iron-Catalyzed Cross-Coupling

B. Sherry and A. F?rstner, Acc. Chem. Res. 2008, 41 (11), 1500-1511

Link: http://pubs.acs.org/doi/full/10.1021/ar800039x

Leonie Mueck