May 082011

U.B. Lushchyk, V.V. Novytskyy

Clinical Hospital “Feofaniya” and Institutes for Mathematics of NAS of Ukraine, Kyiv, Ukraine

Journal of Unsolved Questions, 1, 2, Open Questions, 8-9, 2011 (Received March 29th 2011, published online May 8th 2011)

The cardiovascular system (CVS) is an essential component in  human health, as the background level of functioning of nearly all organs and systems depends on the blood supply level. It is of a very complicated dynamic mechanism by a type of the closed system of connecting vessels with variable parameters in all its structural segments – heart, vascular walls, as well as intravascular fluid – blood.

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Keywords: cardiovascular system, cardiovascular diseases, hydrohemodynamic laws, Non-Newton liquid

  2 Responses to “Which new prospects for an efficient prevention and treatment of cardiovascular diseases could be gained by a systemic examination of the cardiovascular system?”

  1. An interesting article, which demonstrates that a lot of components of cardiac function are represented by optimal vortex formation in the blood flow has been recently published by Morteza Gharib and John O. Dabiri.

    “Optimal vortex formation as an index of cardiac health”
    M. Gharib et al.

    PNAS April 18, 2006 vol. 103 no. 16 6305-6308

  2. The article published here by Lushchyk and Novytskyy points out nicely some of the shortcomings of current medical and also general views on the functionality of the human cardiovascular system, which has important consequences on medical practice and treatment in patients. In addition to these important aspects outlined by the authors, I like to point out the importance of taking also diurnal variations into account, meaning the circadian rhythm which is inherent in many cardiovascular and associated endogenous parameters. Without including internal circadian time into one’s considerations, one runs the potential risk to even declare someone ill who is healthy, by just measuring at the “wrong circadian time”.

    See also e.g. (selection):
    Hastings et al., Nature Reviews Neuroscience, 2003
    Scheer et al., PNAS November 23, 2010 vol. 107 no. 47
    Ivanov et al, PNAS December 26, 2007 vol. 104 no. 52
    Moser et al., Cancer Causes Control (2006) 17:591–599
    Wolk et al., Curr Probl Cardiol, December 2005
    Halberg et al., SCRIPTA MEDICA (BRNO) – 78 (2): 83–88, April 2005
    Roenneberg et al., Sleep Medicine Reviews (2007) 11, 429–438

    With kind regards,
    Thomas Kantermann