Is there a way to figure out whether adrenaline is effective in resuscitation?

According to the international guidelines on resuscitation (see the use of adrenalin is recommended during resuscitation. There is no valid data available regarding the effectiveness of adrenalin. Placebo- controlled trials on this subject are difficult, since the Declaration of Helsinki states, that in research every treatment has to be compared to the state of the art treatment, in order to make sure that any patient participating in a trial receives effective treatment. Furthermore an informed consent in a trial by the patient is difficult in resuscitation, because the patient is not responsive during treatment.

— Johannes Heymer